Limited genetic and antigenic diversity within parasite isolates used in a live vaccine against Theileria parva
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- 作者：Johanneke D. Hemminka ; 1 ; William Weirb ; Niall D. MacHugha ; Simon P. Grahamc ; 1 ; Ekta Patelc ; Edith Paxtona ; Brian Shielsb ; Philip G. Toyec ; W. Ivan Morrisona ; ivan.morrison@roslin.ed.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Roger Pellec
- 关键词：Theileria parva ; Vaccination ; Cattle ; Antigenic diversity ; Gene sequencing ; Satellite DNA
- 刊名：International Journal for Parasitology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：46
- 期：8
- 页码：495-506
- 全文大小：1583 K
文摘
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Genotyping and gene sequencing reveal limited diversity in a live Theileria parva vaccine.
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Two of the vaccine components show a high level of similarity at all loci.
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The vaccine contains very little of the diversity found in field T. parva.
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The vaccine is suboptimal for generating immunity again diverse parasite strains.
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The presence of minor genotypic components poses difficulties for quality control.