Glycolytic Enzymes Localize to Synapses under Energy Stress to Support Synaptic Function
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- 作者：SoRi Jang1 ; 5 ; Jessica C. Nelson1 ; 5 ; Eric G. Bend2 ; Lucelenie Rodrí ; guez-Laureano1 ; Felipe G. Tueros3 ; Luis Cartagenova1 ; Katherine Underwood1 ; Erik M. Jorgensen2 ; Daniel A. Coló ; n-Ramos1 ; 4 ; daniel.colon-ramos@yale.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Neuron
- 出版年：2016
- 出版时间：20 April 2016
- 年：2016
- 卷：90
- 期：2
- 页码：278-291
- 全文大小：2944 K
文摘
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A metabolic compartment forms in vivo near synapses to meet local energy demands
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Under energy stress, glycolytic proteins redistribute to form clusters at synapses
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The glycolytic metabolon is needed for the synaptic vesicle cycle
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Disruption of glycolytic metabolon impairs synaptic recovery and affects locomotion