An LC-MS/MS based candidate reference method for the quantification of total gentamicin in human serum and plasma using NMR characterized calibrator material

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• 作者：Stephanie Lucha^a ; Judith Taibon^a ; Stephan Pongratz^a ; Christian Geletneky^a ; Erasmus Huber^a ; Christine Wintterle-Roehm^a ; Robert Lang^a ; Stefanie H. Grimm^b ; Thomas Duelffer^a ; Kirill Tarasov^a ; Johannes Zander^b ; ^c ; Michael Vogeser^b ; ^{Michael.Vogeser@med.uni-muenchen.de} ; Uwe Kobold^a
• 关键词：Gentamicin ; LC-MS/MS ; Serum ; Plasma ; NMR ; Reference method
• 刊名：Clinica Chimica Acta
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：464
• 期：Complete
• 页码：211-217
• 全文大小：740 K
• 卷排序：464

文摘

LC-MS/MS-based candidate reference method for total gentamicin quantification. NMR characterization of the calibrator material. quantification of individual congeners by quantitative NMR. gentamicin-glycine based IS show identical chromatographic behaviour.