MicroRNAs in the pituitary

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• 作者：Erica Gentilin ; Ettore degli Uberti ; Maria Chiara Zatelli ; MD ; PhD ; ^{ztlmch@unife.it}
• 关键词：miRNA ; pituitary ; miRNA-based therapy ; miRNA biomarkers
• 刊名：Best Practice & Research Clinical Endocrinology & Metabolism
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：30
• 期：5
• 页码：629-639
• 全文大小：275 K
• 卷排序：30

文摘

MicroRNAs (miRNAs) are non-coding RNAs generated from endogenous hairpin-shaped transcripts that powerfully regulate gene expression at post-transcriptional level. Each miRNA is capable to regulate the expression levels of hundreds of transcripts and each mRNA may have more than one miRNA recognition sequence. There is emerging evidence that deregulation of miRNA expression leads to the alteration of pivotal physiological functions contributing to the development of diseases and neoplasms, including pituitary adenoma. This review is aimed at providing the up-to-date knowledge concerning deregulated miRNAs of pituitary tumors and their functions. In order to take stock, pituitary tumors have been sub-divided in different classes on the basis of tumor features (histotype, dimension, aggressiveness). The overview takes full consideration of the recent advances in miRNAs role as potential therapeutics and biomarkers.