Cognitive functions in children exposed to antiepileptic drugs in utero - Study in Georgia

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• 作者：Sofia Kasradze^a ; ^{sofiakas@gmail.com} ; Nino Gogatishvili^a ; ^{nino_gogat@yahoo.com} ; Giorgi Lomidze^a ; ^{lomidzegiorgi@yahoo.com} ; Tamar Ediberidze^a ; ^{ediberidzet@yahoo.com} ; Marine Lazariashvili^a ; ^{lazariashvilimari@ymail.com} ; Ketevan Khomeriki^a ; ^{kkhomeriki@yahoo.com} ; Shorena Mamukadze^a ; ^b ; ^{sh.mamukadze@gmail.com} ; Mariam Metreveli^a ; ^b ; ^{metrmari01@gmail.com} ; Tamar Gagoshidze^a ; ^b ; ^{gagoshidzet@gmail.com} ; Nino Tatishvili^c ; ^{n_tatishvili@hotmail.com} ; Torbj&ouml ; rn Tomson^d ; ^{torbjorn.tomson@karolinska.se}
• 关键词：Fetal AED exposure ; Cognitive teratogenicity ; Multivariate analysis
• 刊名：Epilepsy & Behavior
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：66
• 期：Complete
• 页码：105-112
• 全文大小：440 K
• 卷排序：66

文摘

Fetal exposure to valproate associated with poorer cognitive performance in child Adverse effects of valproate were dose-dependent. Mothers with epilepsy had lower IQ than control mothers confounding associations. Breast-feeding was associated with significantly higher IQ in infant.