Design and cellular studies of a carbon nanotube-based delivery system for a hybrid platinum-acridine anticancer agent

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• 作者：Cale D. Fahrenholtz^a ; ^{cfahrenh@wakehealth.edu} ; Song Ding^b ; ^{dings0@wfu.edu} ; Brian W. Bernish^a ; ^{bbernish@wakehealth.edu} ; Mariah L. Wright^b ; ^{mariah.l.wright@alumni.wfu.edu} ; Ye Zheng^b ; ^{zheny9@wfu.edu} ; Mu Yang^b ; ^{yangm11@wfu.edu} ; Xiyuan Yao^b ; ^{yaox15@wfu.edu} ; George L. Donati^b ; ^{donatigl@wfu.edu} ; Michael D. Gross^b ; ^{grossmd@wfu.edu} ; Ulrich Bierbach^b ; ^c ; ^{bierbau@wfu.edu} ; Ravi Singh^a ; ^c ; ^{rasingh@wakehealth.edu}
• 关键词：Nanoparticle ; Chemotherapy ; Triple negative breast cancer ; Cytotoxicity ; Photothermal therapy ; Drug delivery
• 刊名：Journal of Inorganic Biochemistry
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：165
• 期：Complete
• 页码：170-180
• 全文大小：1519 K
• 卷排序：165

文摘

Efficient coating of a platinum-acridine agent on multi-walled carbon nanotubes Drug release from the nanotube complex following cell uptake Promising therapeutic effect in triple negative breast cancer Nanoparticle-specific induction of S-phase arrest and non-apoptotic cell death Combined photothermal and chemotherapy on a single delivery platform