Quorum Sensing Controls Adaptive Immunity through the Regulation of Multiple CRISPR-Cas Systems

详细信息    查看全文

• 作者：Adrian G. Patterson¹ ; Simon A. Jackson¹ ; Corinda Taylor¹ ; Gary B. Evans² ; George P.C. Salmond³ ; Rita Przybilski¹ ; Raymond H.J. Staals¹ ; Peter C. Fineran¹ ; ⁴ ; ^{peter.fineran@otago.ac.nz}
• 关键词：CRISPR-Cas ; regulation ; quorum sensing ; bacterial communication ; horizontal gene transfer ; phage resistance
• 刊名：Molecular Cell
• 出版年：2016
• 出版时间：15 December 2016
• 年：2016
• 卷：64
• 期：6
• 页码：1102-1108
• 全文大小：1730 K
• 卷排序：64

文摘

Quorum sensing regulates the type I-E, I-F, and III-A CRISPR-Cas systems in Serratia SmaR represses cas gene and CRISPR expression in the absence of AHL signals Both interference and adaptation are modulated by quorum sensing Bacteria coordinate their defenses based on cell density and the risk of infection