The DNA chaperone HMGB1 potentiates the transcriptional activity of Rel1A in the mosquito Aedes aegypti

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• 作者：Anderson de Mendonç ; a Amarante^a ; ^b ; Natapong Jupatanakul^c ; Isabel Caetano de Abreu da Silva^a ; ^b ; Vitor Coutinho Carneiro^a ; ^b ; Amanda Roberta Revoredo Vicentino^a ; ^b ; George Dimopolous^a ; ^b ; ^c ; Octá ; vio Augusto C. Talyuli^a ; ^b ; Marcelo Rosado Fantappié ; ^a ; ^b ; ^{fantappie@bioqmed.ufrj.br}
• 关键词：Aedes aegypiti ; High mobility group B1 protein ; Nf-kB/Rel ; Transcription factor ; DNA bending ; Dengue virus
• 刊名：Insect Biochemistry and Molecular Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：80
• 期：Complete
• 页码：32-41
• 全文大小：1615 K
• 卷排序：80

文摘

AaHMGB1 bends NF-kB/Rel DNA response elements. AaHMGB1 potentiates AaREL1A DNA binding and transcriptional activities. AaHMGB1 acts as an immune modulator in Aedes aegypti.