The ins and outs of phosphosignalling in Plasmodium: Parasite regulation and host cell manipulation

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• 作者：Teresa Gil Carvalho^a ; ¹ ; Belinda Morahan^a ; ¹ ; Simona John von Freyend^a ; ¹ ; Philippe Boeuf^b ; ^c ; ^d ; Georges Grau^e ; Jose Garcia-Bustos^a ; Christian Doerig^a ; ^{christian.doerig@monash.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Malaria ; Plasmodium ; Protein kinase ; Protein phosphatase ; Phosphorylation ; Signalling
• 刊名：Molecular & Biochemical Parasitology
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：208
• 期：1
• 页码：2-15
• 全文大小：2756 K

文摘

Signal transduction and kinomics have been rapidly expanding areas of investigation within the malaria research field. Here, we provide an overview of phosphosignalling pathways that operate in all stages of the Plasmodium life cycle. We review signalling pathways in the parasite itself, in the cells it invades, and in other cells of the vertebrate host with which it interacts. We also discuss the potential of these pathways as novel targets for antimalarial intervention.