Tibolone protects astrocytic cells from glucose deprivation through a mechanism involving estrogen receptor beta and the upregulation of neuroglobin expression
详细信息 查看全文
- 作者：Marco Avila-Rodrigueza ; c ; Luis Miguel Garcia-Segurab ; lmgs@cajal.csic.es" class="auth_mail" title="E-mail the corresponding author ; Oscar Hidalgo-lanussaa ; Eliana Baeza ; Janneth Gonzaleza ; George E. Barretoa ; d ; e ; gsampaio@javeriana.edu.co" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tibolone ; Astrocytes ; Glucose deprivation ; Mitochondria ; ERβ ; Neuroglobin
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：15 September 2016
- 年：2016
- 卷：433
- 期：Complete
- 页码：35-46
- 全文大小：3198 K
文摘
- •
Tibolone protects astrocyte cells from glucose deprivation insult by reducing oxidative damage.
- •
Tibolone protective effect is related with the activation of the Estrogen receptor beta.
- •
Tibolone increases Neuroglobin expression via Estrogen receptor beta activation.