Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons
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- 作者：Luke K. Burke1 ; 2 ; 3 ; 9 ; Barbora Doslikova3 ; 9 ; Giuseppe D'Agostino1 ; 3 ; Megan Greenwald-Yarnell4 ; Teodora Georgescu1 ; Raffaella Chianese1 ; Pablo B. Martinez de Morentin1 ; Emmanuel Ogunnowo-Bada2 ; Celine Cansell1 ; Lourdes Valencia-Torres1 ; 3 ; Alastair S. Garfield3 ; John Apergis-Schoute3 ; Daniel D. Lam5 ; John R. Speakman6 ; 7 ; Marcelo Rubinstein8 ; Malcolm J. Low5 ; Justin J. Rochford1 ; Martin G. Myers4 ; Mark L. Evans2 ; mle24@cam.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Lora K. Heisler1 ; lora.heisler@abdn.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pro-opiomelanocortin (Pomc) ; 5-HT2c receptor ; Obesity ; Energy expenditure ; Brown adipose tissue ; Hyperinsulinemia ; Sexual dimorphism ; Hypothalamus
- 刊名：Molecular Metabolism
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：5
- 期：3
- 页码：245-252
- 全文大小：1755 K
文摘
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Generation of 5-HT2CRYFP mouse line revealed 40% of hypothalamic POMC neurons co-express 5-HT2CRs in male and female mice.
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Pomc expressed exclusively within 5-HT2CR cells modulates energy intake and insulin sensitivity in male and female mice.
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An unexpected sex difference in physical activity and energy expenditure is modulated by hypothalamic Pomc.
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Pomc expressed exclusively within 5-HT2CR cells differentially impacts body weight accumulation in male and female mice.