Secretion of MIP-1β and MIP-1α by CD8⁺ T-lymphocytes correlates with HIV-1 inhibition independent of coreceptor usage

详细信息    查看全文

• 作者：Kevin O. Saunders ; Cavin Ward-Caviness ; Robert J. Schutte ; Stephanie A. Freel ; R. Glenn Overman ; Nathan M. Thielman ; Coleen K. Cunningham ; Thomas B. Kepler ; Georgia D. Tomaras
• 关键词：CD8⁺ T-lymphocyte ; Noncytolytic suppression ; Cytokines ; Chemokine ; HIV-1
• 刊名：Cellular Immunology
• 出版年：2011
• 出版时间：2011
• 年：2011
• 卷：266
• 期：2
• 页码：154-164
• 全文大小：1064 K

文摘

CD8⁺ T-lymphocytes can utilize noncytolytic mechanisms to suppress HIV-1 replication through the secretion of soluble factors. The secretion of MIP-1β, MIP-1α, IP-10, MIG, IL-1α, and interferon gamma correlated most strongly with soluble noncytolytic suppression (p < 0.0001). Since the noncytolytic response is impaired by histone hyperacetylation, we examined the ability of histone hyperacetylation to alter the expression of immune-related genes. MIP-1α and IP-10 were also among the genes that were down-regulated by histone hyperacetylation. We define a multifactorial cytokine profile of CD8⁺ T-lymphocytes capable of mediating noncytolytic suppression of CXCR4-tropic HIV-1 replication.