The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate
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- 作者：Luigi Tortola1 ; 16 ; Roberto Nitsch1 ; 2 ; 16 ; Mathieu J.M. Bertrand3 ; 4 ; Melanie Kogler1 ; Younes Redouane1 ; Ivona Kozieradzki1 ; Iris Uribesalgo1 ; Lilian M. Fennell1 ; Mads Daugaard5 ; 6 ; Helene Klug7 ; Gerald Wirnsberger1 ; Reiner Wimmer1 ; Thomas Perlot1 ; Renu Sarao1 ; Shuan Rao1 ; Toshikatsu Hanada1 ; Nozomi Takahashi3 ; 4 ; Elisabeth Kernbauer8 ; Duygu Demirö ; z8 ; Giulio Superti-Furga9 ; Thomas Decker8 ; Andrea Pichler7 ; Fumiyo Ikeda1 ; Guido Kroemer10 ; 11 ; 12 ; 13 ; 14 ; Peter Vandenabeele3 ; 4 ; Poul H. Sorensen15 ; Josef M. Penninger1 ; josef.penninger@imba.oeaw.ac.at" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：17 May 2016
- 年：2016
- 卷：15
- 期：7
- 页码：1481-1492
- 全文大小：4279 K
文摘
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Hace1 deficiency impairs TNF-driven NF-κB activation and apoptosis
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Necroptosis via RIP1/RIP3/MLKL is still functional in the absence of Hace1
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Hace1–/– animals show enhanced severity of colitis and colon cancer
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Genetic inactivation of RIP3 and TNFR1 reverts the phenotype of hace1–/– mice