Effects of furan on male rat reproduction parameters in a 90-day gavage study
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- 作者：Gerard M. Cooke ; Gerard.Cooke@hc-sc.gc.ca" class="auth_mail ; Marnie Taylor ; Christine Bourque ; Ivan Curran ; Susan Gurofsky ; Santokh Gill
- 关键词：ALP ; alkaline phosphatase ; ALT ; alanine transaminase ; ANOVA ; one-way analysis of variance ; AST ; aspartate transaminase ; Cyp11a1 ; cholesterol side-chain cleavage enzyme ; DHT ; dihydrotestosterone ; FSH ; follicle stimulating hormone ; 3尾-HSD ; 3尾-hydroxysteroid dehydrogenase ; 17尾-HSD ; 17尾-hydroxysteroid dehydrogenase ; LH ; luteinizing hormone ; LHR ; LH receptor ; 17-OHase ; 17-hydroxylase ; C17 ; 20-lyase ; StAR ; steroidogenic acute regulatory protein ; Tspo ; translocator protein
- 刊名：Reproductive Toxicology
- 出版年：July 2014
- 年：2014
- 卷：46
- 期：Complete
- 页码：85-90
- 全文大小：815 K
文摘
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We monitored the effects of subchronic exposure to furan on the male reproductive system.
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Serum testosterone levels were increased serum LH was decreased.
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There were no changes in 17-OHase, 3尾-HSD and 17尾-HSD activities or serum FSH.
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The mRNA level for StAR was increased by all doses of furan.
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The mRNA for Cyp11a1 and intratesticular testosterone were increased by furan.
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We conclude that subchronic furan exposure affects testicular steroidogenesis.