The integrity of corpus callosum and cluster B personality disorders: A quantitative MRI study in juvenile myoclonic epilepsy
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- 作者：Gerardo Maria de Araú ; jo Filho ; Andrea Parolin Jackowski ; Katia Lin ; Ivaldo Silva ; Mirian S.B. Guaranha ; Laura M.F.F. Guilhoto ; Henrique Carrete Jú ; nior ; Elza Má ; rcia T. Yacubian ; Rodrigo
- 关键词：Cluster B personality disorders ; Corpus callosum ; Idiopathic generalized epilepsy ; Juvenile myoclonic epilepsy ; Magnetic resonance imaging ; Psychiatric disorders
- 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
- 出版年：2010
- 出版时间：16 April 2010
- 年：2010
- 卷：34
- 期：3
- 页码：516-521
- 全文大小：283 K
文摘
Evidence suggests increased prevalence of cluster B personality disorders (PD) among patients with juvenile myoclonic epilepsy (JME), which has been associated with worse seizure control and more psychosocial dysfunctions. A preliminary voxel-based morphometry study demonstrated corpus callosum (CC) volume reduction in patients with JME and cluster B PD, particularly in the posterior midbody and isthmus. In this study we aimed to follow up these results with region of interest analysis. Sixteen JME patients with cluster B PD, 38 JME patients without any psychiatric disorder, and 30 demographically matched healthy controls submitted to a psychiatric evaluation and a magnetic resonance imaging scan. The total and regional callosal areas were obtained from the midsagittal slice using a semi-automated program. Psychiatric evaluation was performed through SCID-I and -II. Significant reductions in the posterior region of the CC were observed in the JME with PD group relative to the other groups. These data support previous findings of callosal reductions in cluster B PD, as well as a possible involvement of CC in patients with JME and such personality characteristics.