Duloxetine enters the brain - But why is it not found in the cerebrospinal fluid
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- 作者：Michael Paulzena ; mpaulzen@ukaachen.de" class="auth_mail" title="E-mail the corresponding author ; Gerhard Grü ; ndera ; Tanja Veselinovica ; Bernhard Wolfb ; Christoph Hiemkec ; Sarah E. Lammertza
- 关键词：BCSFB ; blood-cerebrospinal-fluid-barrier ; BBB ; blood-brain-barrier ; CNS ; central nervous system ; CSF ; cerebrospinal fluid
- 刊名：Journal of Affective Disorders
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：189
- 期：Complete
- 页码：159-163
- 全文大小：285 K
文摘
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Unlike other antidepressant drugs, duloxetine is hardly found in CSF.
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Low concentrations are indicative for a low penetration into or an active transport out of the CSF.
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Sufficiently high drug levels at the target sites are not reflected in CSF concentrations.