Mapping Complex Traits in a Diversity Outbred F1 Mouse Population Identifies Germline Modifiers of Metastasis in Human Prostate Cancer

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• 作者：Jean M. Winter¹ ; ⁸ ; Derek E. Gildea² ; ⁸ ; Jonathan P. Andreas¹ ; Daniel M. Gatti³ ; Kendra A. Williams¹ ; Minnkyong Lee¹ ; Ying Hu⁴ ; Suiyuan Zhang² ; NISC Comparative Sequencing Program⁵
• 关键词：neuroendocrine prostate cancer ; metastasis ; RWDD4 ; CENPU ; CASP3 ; diversity outbred ; DO ; TRAMP mouse model ; modifier locus mapping ; germline modifiers ; systems genetics
• 刊名：Cell Systems
• 出版年：2017
• 出版时间：25 January 2017
• 年：2017
• 卷：4
• 期：1
• 页码：31-45.e6
• 全文大小：4680 K
• 卷排序：4

文摘

Comparative genetics is a powerful alternative to GWAS to identify modifier genes Highly polymorphic “Diversity Outbred” mice enable high-resolution genetic mapping Modifiers identified by integrating human and mouse germline and expression data CENPU, RWDD4, and CASP3 are germline modifiers of aggressive prostate cancer