In vitro anticancer properties and biological evaluation of novel natural alkaloid jerantinine B
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- 作者：Mohannad E. Qazzaza ; Vijay J. Rajaa ; Kuan-Hon Limb ; Toh-Seok Kamc ; Jong Bong Leea ; Pavel Gershkovicha ; Tracey D. Bradshawa ; tracey.bradshaw@nottingham.ac.uk" class="auth_mail" title="E-mail the corresponding author ; paxmq@nottingham.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：EB 1 ; end-binding protein 1 ; JB ; jerantinine B ; JBA ; jerantinine B acetate ; MTA ; microtubule targeting agent ; NP ; natural product ; ROS ; reactive oxygen species ; PLK1 ; Polo-like kinase 1
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 January 2016
- 年：2016
- 卷：370
- 期：2
- 页码：185-197
- 全文大小：4171 K
文摘
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Natural product indole alkaloid.
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Anticancer activity.
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Elucidation of mechanisms of action: Microtubule disrupting agent; inhibitor of PLK1; generation of reactive oxygen species.