Could heart rate play a role in pericardial inflammation?
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- 作者：Ziad Khoueiry ; Camille Roubille ; Nicolas Nagot ; Beno?t Lattuca ; Christophe Piot ; Florence Leclercq ; Delphine Delseny ; David Busseuil ; Richard Gervasoni ; Jean-Marc Davy ; Jean-Luc Pasqui¨¦ ; Fr¨¦d¨¦ric Cransac ; Catherine Sportouch-Dukhan ; Jean-Christophe Macia ; Thien-Tri Cung ; Fran?ois Massin ; St¨¦phane Cade ; Jean-Paul Cristol ; St¨¦phanie Barr¨¨re-Lemaire ; Fran?ois Roubille ; et al.
- 刊名：Medical Hypotheses
- 出版年：2012
- 出版时间：October, 2012
- 年：2012
- 卷：79
- 期：4
- 页码：512-515
- 全文大小：186 K
文摘
Purpose and medical hypothesis: Rest is usually recommended in acute pericarditis, as it could help to lower heart rate (HR) and contribute to limit ¡°mechanical inflammation¡±. Whether HR on admission could be correlated and perhaps participate to inflammation has not been reported. Methods: Between March 2007 and February 2010, we conducted a retrospective study on all patients admitted to our center for acute pericarditis. Diagnosis criteria included two of the following ones: typical chest pain, friction rub, pericardial effusion on cardiac echography, or typical electrocardiogram (ECG) findings. Primary endpoint was biology: CRP on admission, on days 1, 2, 3, and especially peak. Results: We included 73 patients. Median age was 38 years (interquartiles 28-51) and median hospitalization duration was 2.0 days (1.5-3.0). Median heart rate was 88.0 beats per minute (bpm) on admission (interquartiles 76.0-100.0) and 72.0 on discharge (65.0-80.0). Heart rate on admission was significantly correlated with CRP peak (p < 0.001), independently of temperature on admission, hospitalization duration and age. Recurrences occurred within 1 month in 32 % of patients. Heart rate on hospital discharge was correlated with recurrence, independently of age. Conclusion: In acute pericarditis, heart rate on admission is independently correlated with CRP levels and heart rate on discharge seems to be independently correlated to recurrence. This could suggest a link between heart rate and pericardial inflammation.