A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program
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- 作者：Vijayendran Chandran1 ; Giovanni Coppola1 ; 8 ; Homaira Nawabi2 ; Takao Omura2 ; Revital Versano1 ; Eric A. Huebner2 ; Alice Zhang3 ; Michael Costigan2 ; Ajay Yekkirala2 ; Lee Barrett2 ; Armin Blesch4 ; 9 ; Izhak Michaelevski5 ; 10 ; Jeremy Davis-Turak1 ; 11 ; Fuying Gao8 ; Peter Langfelder6 ; 7 ; Steve Horvath6 ; 7 ; Zhigang He2 ; Larry Benowitz2 ; Mike Fainzilber5 ; Mark Tuszynski4 ; Clifford J. Woolf2 ; Daniel H. Geschwind1 ; 6 ; dhg@mednet.ucla.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Neuron
- 出版年：2016
- 出版时间：2 March 2016
- 年：2016
- 卷：89
- 期：5
- 页码：956-970
- 全文大小：6894 K
文摘
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We identify a transcriptional program observed after PNS, but not CNS injury
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This program links known signaling pathways via a core set of transcription factors
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We experimentally and bio-informatically validate several network predictions
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We use the core transcriptional profile to identify a drug that promotes regeneration