Genotoxic effects of camphorquinone and DMT on human oral and intestinal cells
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- 作者：Miriam Wessels1 ; wessels.miriam@mh-hannover.de" class="auth_mail" title="E-mail the corresponding author ; Julia Rimkus1 ; Gabriele Leyhausen ; Joachim Volk ; Werner Geurtsen
- 关键词：Camphorquinone ; Reactive oxygen species ; DNA damage ; 8-Oxoguanine
- 刊名：Dental Materials
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：31
- 期：10
- 页码：1159-1168
- 全文大小：1389 K
文摘
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Camphorquinone (CQ) induced DNA lesions in OKF6/TERT2 and Caco-2 cells.
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This DNA damage is mainly caused by the generation of 8-oxoguanine.
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The antioxidant glutathione prevented CQ-associated DNA damage in Caco-2 cells.
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Recovery following CQ-treatment significantly reduced DNA damage in Caco-2 cells.