Marked Differences in C9orf72 Methylation Status and Isoform Expression between C9/ALS Human Embryonic and Induced Pluripotent Stem Cells
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- 作者：Yaara Cohen-Hadad1 ; Gheona Altarescu2 ; Talia Eldar-Geva3 ; Ephrat Levi-Lahad2 ; Ming Zhang4 ; Ekaterina Rogaeva4 ; Marc Gotkine5 ; Osnat Bartok6 ; Reut Ashwal-Fluss6 ; Sebastian Kadener6 ; Silvina Epsztejn-Litman1 ; Rachel Eiges1 ; rachela@szmc.org.il" class="auth_mail" title="E-mail the corresponding author
- 关键词：C9/ALS ; unstable repeat expansions ; DNA methylation ; CpG islands ; pluripotent stem cells ; disease modelling ; neurodegeneration
- 刊名：Stem Cell Reports
- 出版年：2016
- 出版时间：8 November 2016
- 年：2016
- 卷：7
- 期：5
- 页码：927-940
- 全文大小：3214 K
文摘
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Derivation of two C9 hESC lines, haploidentical and unrelated C9 iPSCs
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Striking difference in C9 methylation and transcription between C9 hESCs and iPSCs
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Upregulation of repeat-containing mRNAs by differentiation, exclusively in C9 hESCs
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Supports the role for C9 methylation as a neuroprotective mechanism