Structural and Functional Analysis of the Cdk13/Cyclin K Complex
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- 作者：Ann Katrin Greifenberg1 ; 2 ; Dana Hö ; nig2 ; 3 ; Kveta Pilarova4 ; Robert Dü ; ster1 ; 2 ; Koen Bartholomeeusen4 ; Christian A. Bö ; sken2 ; 3 ; Kanchan Anand1 ; 5 ; Dalibor Blazek4 ; Matthias Geyer1 ; 2 ; 3 ; geyer@uni-bonn.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：transcription ; Cdk13 ; Cyclin K ; Pin1 ; RNA polymerase II ; flavopiridolIntroduction
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：12 January 2016
- 年：2016
- 卷：14
- 期：2
- 页码：320-331
- 全文大小：4706 K
文摘
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The crystal structure of the human Cdk13/Cyclin K complex
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Cdk13 phosphorylates Ser5 and Ser2 of the RNA polymerase II CTD
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The isomerase Pin1 does not change the phosphorylation specificity of Cdk13
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Cdk13 regulates genes involved in growth signaling pathways