Thyroid hormone is required for the pruning of afferent type II spiral ganglion neurons in the mouse cochlea
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- 作者：S. Sundaresan ; S. Balasubbu ; M. Mustapha ; mirnam@stanford.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ANOVA ; analysis of variance ; BDNF ; brain-derived neurotrophic factor ; EDTA ; ethylenediaminetetraacetic acid ; GAPDH ; glyceraldehyde-3-phosphate dehydrogenase ; GFP ; Green fluorescent protein ; GLUTR ; glutamate receptor ; IHC ; inner hair cell ; MGFP ; Mafb-GFP ; Ntf3 ; neurotrophin 3 ; OHC ; outer hair cell ; OTOF ; otoferlin ; PBS ; phosphate-buffered saline ; PGFP ; peripherin-GFP ; PTU ; propylthiouracil ; SGN ; spiral ganglion neuron ; TEM ; transmission electron microscopy ; TH ; thyroid hormone ; WT ; wild type
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：312
- 期：Complete
- 页码：165-178
- 全文大小：2656 K
文摘
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Hypothyroid mice retain excess afferent innervation to outer hair cells.
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Excess innervation is made up of type II spiral ganglion neurons.
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Otoferlin expression persists in the outer hair cells of hypothyroid mice.
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Thyroid hormone given from postnatal day 3–4 restores normal afferent innervation.
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Afferent pruning may not be regulated by the state of hair cell maturation.