6-Methylpurine derived sugar modified nucleosides: Synthesis and evaluation of their substrate activity with purine nucleoside phosphorylases
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- 作者：Abdalla E.A. Hassana ; b ; abdallaelsayed@zu.edu.eg" class="auth_mail" title="E-mail the corresponding author ; Reham A.I. Abou-Elkhaira ; William B. Parkera ; c ; Paula W. Allana ; John A. Secrist IIIa
- 关键词：6-Methylpurine ; 2-Fluoroadenine ; Purine nucleosides ; Vorbrü ; ggen glycosylation ; Purine nucleoside phosphorylase ; Cancer gene therapy
- 刊名：Bioorganic Chemistry
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：65
- 期：Complete
- 页码：9-16
- 全文大小：536 K
文摘
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Methyl(allo)-MeP-R; 3 and 5′-C-di-methyl-MeP-R; 4 were synthesized as potential prodrugs of 6-MeP.
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The substrate activity 3 and 4 were evaluated with several phosphorylase enzymes.
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Both 3 and 4 were poor substrates against all tested phosphorolysis enzymes.