Geranylgeranyl pyrophosphate performs as an endogenous regulator of adipocyte function via suppressing the LXR pathway
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- 作者：Yu-Sheng Yeha ; Tsuyoshi Gotoa ; b ; tgoto@kais.kyoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Nobuyuki Takahashia ; b ; Kahori Egawaa ; Haruya Takahashia ; Huei-Fen Jhenga ; Young-Il Kima ; Teruo Kawadaa ; b
- 关键词：GGPP ; Adipocyte differentiation ; Antagonist ; LXR ; Metabolic syndrome
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：23 September 2016
- 年：2016
- 卷：478
- 期：3
- 页码：1317-1322
- 全文大小：1058 K
文摘
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Intracellular GGPP levels are enhanced during adipocyte differentiation.
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GGPP suppresses adipocyte differentiation and maturation.
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The inhibitory effects of GGPP are partially through the LXRs signaling pathway.