Synthesis of new thermo/pH sensitive drug delivery systems based on tragacanth gum polysaccharide
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- 作者：Khadijeh Hemmati ; Mousa Ghaemy ; ghaemy@umz.ac.ir" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tragacanth gum polysaccharide ; Comb-type copolymer ; Drug delivery ; ATRP ; Click chemistry
- 刊名：International Journal of Biological Macromolecules
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：87
- 期：Complete
- 页码：415-425
- 全文大小：2002 K
文摘
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New responsive comb-type graft copolymers were synthesized as nanocarriers.
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Nanocarriers were prepared based on natural gum by ROP, ATRP, and “click” chemistry.
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The nanocarriers were fully characterized and self-assembled to micelles in water.
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Size, morphology and cytotoxicity of the nanomicelles were investigated.
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The in vitro drug release kinetics and mechanism were investigated.