Modulation by female sex hormones of the cannabinoid-induced catalepsy and analgesia in ovariectomized mice

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• 作者：Dina Kalbasi Anaraki ; Setareh Sianati ; Mahsa Sadeghi ; Mehdi Ghasemi ; Parvin Javadi ; Shahram Ejtemaei Mehr ; Ahmad RezaDehpour
• 关键词：Cannabinoids ; Catalepsy ; Analgesia ; Ovarian sex hormones ; Estrogen ; Progesterone ; [Mouse]
• 刊名：European Journal of Pharmacology
• 出版年：2008
• 出版时间：31 May 2008
• 年：2008
• 卷：586
• 期：1-3
• 页码：189-196
• 全文大小：423 K

文摘

Cannabinoids are psychoactive compounds with many pharmacological properties such as analgesia, sedation and catalepsy most of which are mediated by cannabinoid CB₁ receptors. In the present study, we evaluated whether the ovarian sex hormones are involved in the cannabinoid-induced catalepsy and analgesia in ovariectomized female mice. Female NMRI mice (weighing 25–30 g) were divided into 3 main groups: unoperated, sham-operated and ovariectomized. Both the catalepsy and analgesia induced by different doses of the synthetic cannabinoid WIN 55,212-2 (2 and 4 mg/kg, i.p.) were examined in the groups in the presence or absence of the cannabinoid CB₁ antagonist AM251 (0.5 mg/kg). We also evaluated effects of estradiol valerate (10 mg/kg) and progesterone (25 mg/kg) on catalepsy and analgesia induced by WIN 55,212-2 in ovariectomized mice. The antinociceptive effect of WIN 55,212-2 was significantly (P < 0.01) enhanced in ovariectomized mice, which was prevented by pretreatment with estradiol but not by progesterone. There was no significant difference in the cannabinoid-induced catalepsy between control and ovariectomized mice. However, pretreatment with progesterone but not estradiol potentiated the cataleptic effect of low dose of WIN 55,212-2 (2 mg/kg) in ovariectomized mice (P < 0.01). The present data demonstrated for the first time that ovarian sex steroids could modulate both cannabinoid-induced catalepsy and analgesia in female ovariectomized mice.