La leucémie aiguë peu différenciée (MO) aspects hématologiques, immunophénotypiques, cytogénétiques, incidence pronostique: Expérience au chu de caen

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• 作者：Sophie Bustanya ; Michè ; le Malet ; Vé ; ronique Salaun ; Dina Naguib ; Ghislaine Plessis ; Xavier Troussard
• 关键词：Leucé ; mie aiguië ; myé ; loï ; de peu diffé ; rencié ; e - LAMO - é ; tude ré ; trospective - facteurs pronostics.
• 刊名：Revue Francophone des Laboratoires
• 出版年：2007
• 出版时间：September-October 2007
• 年：2007
• 卷：2007
• 期：395
• 页码：51-58
• 全文大小：24025 K

文摘

Summary

Acute myeloid leukaemia with minimal differentiation: morphological identification, immunophenotypic and cytogenetic analysis, pronostic incidence

AMLO or acute myeloid leukaemia with minimal differentiation accounts for 6 to 10 % of patients AML. AMLO or acute myeloid leukaemia with minimal differentiation accounts for 6 to 10 % of patients AML. The incidence is higher in the elderly. Diagnosis is based on morphological identification, cytochemical reactions and immunophenotypic analysis.

No recurent cytogenetic specific abnormalities were described in AMLO but a few of them are more frequent in this pathology (trisomies 8 and 13, monosomies 5 and 7, anomalities of chromosome 11). The clinical outcome is specially poor with a high mortafity (> 50 % ) one year after diagnosis. Research about intraceflular modifications of AMLO blast cells could and would lead to ameliorate the follow-up of patients and certainly help to the emergence of new treatments. Acute myeloid leukaemia with minimal differentiation - AMLO - retrospective study - prognostic factors.