Psychiatric disorders and psychological distress in patients undergoing evaluation for lung transplantation: a national cohort study

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• 作者：Torunn S. Sø ; yseth ; P.T. ; M. Sc.^a ; May-Brit Lund ; M.D. ; Ph.D.^b ; Ø ; ystein Bjø ; rtuft ; M.D. ; Ph.D.^b ; Aasta Heldal ; M.D.^c ; Vidar Sø ; yseth ; M.D. ; Ph.D.^e ; ^f ; Mary Amanda Dew ; Ph.D.^g ; Gro Killi Haugstad ; P.T. ; Ph.D.^h ; Ulrik Fredrik Malt ; M.D. ; Ph.D.^c ; ^d ; ^f ; ^{u.f.malt@medisin.uio.no" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Depression ; Anxiety ; COPD ; Lung function ; Lung transplantation
• 刊名：General Hospital Psychiatry
• 出版年：2016
• 出版时间：September-October 2016
• 年：2016
• 卷：42
• 期：Complete
• 页码：67-73
• 全文大小：298 K

文摘

We sought to investigate type and prevalence of psychiatric disorders and psychological distress in patients being evaluated for lung transplantation.

Methods

One hundred eighteen patients were assessed [74% with chronic obstructive pulmonary disease (COPD)] with the MINI Neuropsychiatric Interview, the General Health Questionnaire (GHQ), and Hospital Anxiety Depression Scale (HADS). Spirometry and the 6-min walk test (6MWT) assessed lung function with data subject to multivariate regression analyses.

Results

Current and lifetime prevalence for mental disorders were 41.5% and 61.0% respectively, with anxiety (39.8% of patients), mood disorders (11.8%), and subsyndromal disorders (8.7%) identified. 15% of patients reported feelings of panic during the last week, 9% reported hopelessness, and 3% felt that life was not worth living. Statistically significant correlates were derived for HADS-depression with lung function (P=.0012) and 6MWT (P=.030) for the entire group (P=.012), and with lung function (P=.030) for COPD patients (P=.045), for whom higher chronic GHQ-scores correlated with poorer lung function (P=.009). In multivariate regression analysis, history of mental disorder was strongest predictor of current distress.

Conclusions

Our findings underline the importance of assessing past, current, and sub-syndromal psychiatric disorders in addition to levels of distress in transplant candidates, with prospective studies needed to investigate impact on long-term outcome after transplantation.