Scavenger receptor class-A plays diverse role in innate immunity, cell signaling and different pathologies

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• 作者：Aamir Rana^a ; ^{aamirrana_grg@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Syed Sajjad Sattar^b ; Afshann Shahzad^c ; Ghulam Muhammad Ali^a ; Yasir Waheed^d
• 关键词：Scavenger receptors ; Innate immunity ; Interleukins ; Cell signaling ; Apoptosis
• 刊名：Asian Pacific Journal of Tropical Disease
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：6
• 期：7
• 页码：567-572
• 全文大小：573 K

文摘

Evidences have been increasingly provided to comfirm that lipid accumulation in cells contributes to the progression of pathogeneses. The receptor-mediated lipid uptake is the crucial step for lipid retention as scavenger receptors class-A (SR-A) is not controlled via negative feedback by cytoplasmic cholesterol and therefore it plays a fundamental role in the formation of foam cells. Along with participation in apoptosis, SR-A presents very deceitful characteristics to control immune responses during age-related degenerative pathologies such as atherosclerosis and Alzheimer's disease. It is henceforth undeniable that targeted inhibition of these receptors will be helpful in getting a step closer to individualized medicine. This review unfolds current understanding of SR-A signaling with a focus on its role in apoptosis and immune regulation during different pathologies.