Biomarkers of lymphoma in Sj枚gren鈥檚 syndrome and evaluation of the lymphoma risk in prelymphomatous conditions: Results of a multicenter study
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- 作者：Luca Quartuccioa ; quarto77@gmail.com" class="auth_mail ; Miriam Isolab ; Chiara Baldinic ; Roberta Priorid ; Elena Bartoloni Boccie ; Francesco Carubbif ; Marta Maseta ; Giorgia Gregoracib ; Vincenzo Della Meag ; Sara Salvina ; Ginevra De Marchia ; Nicoletta Lucianoc ; Serena Colafrancescod ; Alessia Alunnoe ; Roberto Giacomellif ; Roberto Gerlie ; Guido Valesinid ; Stefano Bombardieric ; Salvatore De Vitaa ; devita.salvatore@aoud.sanita.fvg.it" class="auth_mail
- 关键词：Sjö ; gren's syndrome ; Lymphoma ; Cryoglobulinemia
- 刊名：Journal of Autoimmunity
- 出版年：June 2014
- 年：2014
- 卷：51
- 期：Complete
- 页码：75-80
- 全文大小：255 K
文摘
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Lymphoma risk was studied in different subsets of pSS.
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Cryoglobulinemia, low C4, anti-SSB/La antibodies and leukopenia were significantly associated with lymphoma in pSS.
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Presence of ≤1 biomarker provided a high negative predictive value for lymphoma.
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Patients with salivary swelling and with positive biomarkers may be at higher risk for lymphoma.