• 作者：Michael Bauer^a ; ^b ; ^{michael.bauer@med.uni-jena.de" class="auth_mail" title="E-mail the corresponding author} ; Evangelos J. Giamarellos-Bourboulis^b ; ^c ; Andreas Kortgen^a ; ^b ; Eva Mö ; ller^d ; Karen Felsmann^d ; Jean Marc Cavaillon^e ; Orlando Guntinas-Lichius^f ; Olivier Rutschmann^g ; Andriy Ruryk^b ; Matthias Kohl^h ; Britta Wlotzkaⁱ ; Stefan Ruß ; wurm^a ; John C. Marshall^j ; Konrad Reinhart^a ; ^b
• 关键词：Host response ; Transcriptomic profiling ; Adaptive immunity ; Point-of-care ; RT-qPCR ; Clinical utility
• 刊名：EBioMedicine
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：6
• 期：Complete
• 页码：114-125
• 全文大小：1865 K

•

Pro- and anti-inflammatory signaling occurs simultaneously in the host response to infection.

•

This response is currently monitored using biomarkers restricted to the pro-inflammatory component of innate immunity.

•

We developed a biomarker panel consisting of 7 transcripts that can assess both facets at the point of care.

The concept that a selective, overwhelming systemic inflammation, the “Systemic Inflammatory Response Syndrome (SIRS)”, triggers organ failure subsequent to infection has lately been abandoned as it neglects parallel occurring anti-inflammatory responses or defects in the adaptive immune system.

The present findings suggest that a compound panel of nucleic acid biomarkers that was developed in independent training and verification cohorts and transferred to a point-of-care platform can more comprehensively describe the host response. Quantification of an enhanced innate immunity might inform studies of anti-inflammatory therapies, while measurement of derangements in specific immunity might guide strategies to restore immune effector functions.