Defective production of interleukin-1 beta in patients with type 2 diabetes mellitus: Restoration by proper glycemic control

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• 作者：Foteini Kousathana^a ; Marianna Georgitsi^b ; Vaia Lambadiari^a ; Evangelos J. Giamarellos-Bourboulis^b ; ^{egiamarel@med.uoa.gr} ; George Dimitriadis^a ; Maria Mouktaroudi^b
• 关键词：Interleukin-1 ; Interleukin-6 ; Diabetes mellitus ; Glycemic control
• 刊名：Cytokine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：90
• 期：Complete
• 页码：177-184
• 全文大小：1247 K
• 卷排序：90

文摘

Type 2 diabetes is associated with risk for inadequate IL-1β monocyte responses. Down-regulation of monocyte NLRP3 inflammasome activation is described. Increased monocyte IL-6 release is also shown. Modulated monocyte function is restored by proper glycemic control.