The predictive role of both NT-proANP and NT-proBNP circulating levels toward cardiovascular outcome was assessed in a cohort of both stable and unstable CAD patients undergoing PCI in a non-primary PCI setting.

Following PCI, higher levels of both NT-proNPs were associated to higher occurrence of MACEs [composite of cardiac death, non-fatal myocardial infarction and clinically driven target lesion revascularization (c-TLR)] at follow up.

Notably, NT-proANP levels were an independent predictor of MACEs by Cox regression analysis. Kaplan–Meyer curves revealed that patients with elevated NT-proANP levels (> 2.100 fmol/mL) had a lower MACE free survival (p = 0.003).

Our findings support the key role of natriuretic peptides in ischemic heart disease.