A novel compound of triphenyltin(IV) with N-tert-butoxycarbonyl-l-ornithine causes cancer cell death by inducing a p53-dependent activation of the mitochondrial pathway of apoptosis

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• 作者：Maria Assunta Girasolo^a ; ^{assunta.girasolo@unipa.it} ; Luisa Tesoriere^a ; Girolamo Casella^b ; ^e ; Alessandro Attanzio^a ; Massimo L. Capobianco^c ; Piera Sabatino^d ; Giampaolo Barone^a ; ^e ; Simona Rubino^a ; Riccardo Bonsignore^a
• 关键词：Triphenyltin(IV) ; Boc-Orn-OH ; NMR ; Antitumor agents ; Apoptosis
• 刊名：Inorganica Chimica Acta
• 出版年：2017
• 出版时间：24 February 2017
• 年：2017
• 卷：456
• 期：Complete
• 页码：1-8
• 全文大小：1210 K
• 卷排序：456

文摘

Triphenyltin(IV) compound with N-tert-butoxycarbonyl-l-ornithine has been synthesized. Antiproliferative activity was evaluated in vitro on different tumor cell lines. IC50 values are from 20 to 60 times lower than cisplatin. Ph3Sn(Boc-Orn-O) induced apoptosis of HepG2 cells via mitochondria-dependent pathway.