c-FLIP-/- MEFs are more resistant than WT MEFs to ER stress-mediated apoptosis
Analysis of UPR pathways reveals that PERK and IRE1 branch signalling is compromised in c-FLIP-/- cells vs WT cells
c-FLIP modulates the PERK pathway by interfering with the activity of the serine threonine kinase AKT
c-FLIP-/- MEFs display higher levels of active AKT than WT MEFs upon ER stress
Treatment with a specific AKT inhibitor of c-FLIP-/- MEFs subjected to ER stress restores the PERK but not the IRE1 pathway
AKT inhibition sensitizes c-FLIP-/- cells to ER stress-induced cell death