Chemical-physical properties and cytotoxicity of N-decanoyl amino acid-based surfactants: Effect of polar heads
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- 作者：Diego R. Perinellia ; Luca Casettarib ; Marco Cespia ; Francesco Finib ; Dede K.W. Manc ; Gianfabio Giorgionia ; Silvia Canalaa ; Jenny K.W. Lamc ; Giulia Bonacucinaa ; giulia.bonacucina@unicam.it" class="auth_mail" title="E-mail the corresponding author ; Giovanni F. Palmieria
- 关键词：Amino acids based surfactants ; Critical micelle concentration (CMC) ; Cytotoxicity ; MTT assay ; LDH assay ; Hemolytic assay
- 刊名：Colloids and Surfaces A: Physicochemical and Engineering Aspects
- 出版年：2016
- 出版时间：5 March 2016
- 年：2016
- 卷：492
- 期：Complete
- 页码：38-46
- 全文大小：2103 K
文摘
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N-Decanoyl aminoacyl derivates were analyzed at physiological pH in comparison to SDS.
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Toxicological profile was assessed by MTT, LDH, hemolytic assays and TEER tests.
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N-Decanoyl surfactants were less toxic than SDS in tested cell lines and erythrocytes.
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Hydrophilic interactions amphiphiles/cell membranes determined cellular toxicity.
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Polar heads affect the aggregation state and cell toxicity profiles.