Dimeric l-Dopa Derivatives as Potential Prodrugs

详细信息    查看全文

• 作者：Di Stefano ; Antonio ; Mosciatti ; Barbara ; Mario Cingolani ; Gian ; Giorgioni ; Gianfabio ; Ricciutelli ; Massimo ; et. al.
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2001
• 出版时间：April 23, 2001
• 年：2001
• 卷：11
• 期：8
• 页码：1085-1088
• 全文大小：142 K

文摘

A series of dimeric derivatives (+)-1, and (+)-2, and (+)-3a–d of l-Dopa diacetyl esters was synthesized and evaluated as potential l-Dopa prodrugs with improved physicochemical properties. All the new compounds showed chemical stability in aqueous buffer solutions (pH 1.3 and 7.4). A relatively slow release of l-Dopa in human plasma was observed.