B cells and HCV: An infection model of autoimmunity
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- 作者：Loredana Sansonno ; Felicia Anna Tucci ; Silvia Sansonno ; Gianfranco Lauletta ; Laura Troiani ; Domenico Sansonno
- 关键词：B-cell expansion ; HCV infection ; Mixed cryoglobulinemia
- 刊名：Autoimmunity Reviews
- 出版年：2009
- 出版时间：December 2009
- 年：2009
- 卷：9
- 期：2
- 页码：93-94
- 全文大小：112 K
文摘
In addition to cause acute and chronic liver disease, hepatitis C virus (HCV) infection is frequently associated to autoimmune disorders, such as mixed cryoglobulinemia, primary glomerulonephritis, monoclonal gammopathy of undetermined significance and post-transplant proliferative disorders. Progression to malignant phenotype of B cells may be the consequence of additional genetic events or abnormal conditions resulting from modification of host cell genes involved in the control of oncogenes and oncoproteins.
In this review, we will address the potential immune disregulatory mechanism(s) underlying HCV persistence. In addition, HCV/B-cell interaction that might explain defects in humoral immunity in individuals who develop chronic virus carriage and lymphoproliferative disorders will be emphasized.