Immunophenotypic characterization of IgV_H3-72 B-cell chronic lymphocytic leukaemia (B-CLL)

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• 作者：Daniela Capello ; Antonella Zucchetto ; Massimo Degan ; Riccardo Bomben ; Michele Dal Bo ; Dimitar G. Efremov ; Luca Laurenti ; Giovanni Del Poeta ; Gianluca Gaidano and Valter Gattei
• 关键词：CLL ; Prognosis ; Immunophenotype
• 刊名：Leukemia Research
• 出版年：2006
• 出版时间：September 2006
• 年：2006
• 卷：30
• 期：9
• 页码：1197-1199
• 全文大小：88 K

文摘

The frequent expression of the otherwise rare IgV_H3-72 gene was demonstrated in highly stable B-cell chronic lymphocytic leukaemias (B-CLLs). Here we describe the immunophenotypic profiles of eleven IgV_H3-72 B-CLLs, by investigating expression of ZAP-70 and of a set of surface antigens previously demonstrated to represent the signature of distinct B-CLL prognostic groups. All IgV_H3-72 B-CLLs revealed a homogeneous immunophenotypic profile, expressing all the markers associated with good prognosis, but not those representing the signature of bad prognosis B-CLLs, including ZAP-70. Our results corroborate the notion that IgV_H3-72 B-CLLs represent a molecularly and immunophenotypically homogeneous disease group with a good prognosis.