Multicenter study of two new generation detectors for CyberKnife output factors. All CyberKnife models presently in clinical use included in the study. PTW-60019 and Exradin W1 responses compared to Monte Carlo corrected E-diodes. The uncertainties related to Čerenkov effect for W1 scintillator are evaluated. MicroDiamond and W1 scintillator output factors within 1.5% of corrected E-diode.