Discovery of new C3aR ligands. Part 2: Amino-piperidine derivatives
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- 作者：Fré ; dé ; ric Denonne ; Sophie Binet ; Maggi Burton ; Philippe Collart ; Sabine Defays ; Alan Dipesa ; Maria Eckert ; Alex ; er Giannaras ; Seema Kumar ; Beth Levine ; et al.
- 关键词：C3a ; Inflammation ; SAR ; Agonist
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2007
- 出版时间：15 June 2007
- 年：2007
- 卷：17
- 期：12
- 页码：3262-3265
- 全文大小：125 K
文摘
The synthesis and structure–activity relationships against the C3a receptor of a series of substituted aminopiperidine derivatives are reported. DMPK properties and functional activities of selected compounds are described. The compounds obtained are the first non-arginine ligands of C3aR.