Investigating a new drug delivery nano composite membrane system based on PVA/PCL and PVA/HA(PEG) for the controlled release of biopharmaceuticals for bone infections

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• 作者：Taoyu Wanp>ap>p> ; p>p>bp> ; George K. Styliosp>bp>p> ; p>p>G.Stylios@hw.ac.uk" class="auth_mail" title="E-mail the corresponding authorp> ; Marilena Giannoudip>cp> ; Peter V. Giannoudisp>cp>p> ; p>p>dp>
• 关键词：drug delivery ; poly(e-caprolactone) ; PVA hydrogels ; bone infections ; controlled delivery ; nano composite ; nano membrane
• 刊名：Injury
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：46
• 期：supp_S8
• 页码：S39-S43
• 全文大小：1267 K

文摘

The capability for sustained and gradual release of pharmaceuticals is a major requirement in the development of a guided antimicrobial bacterial control system for clinical applications. In this study, PVA gels with varying constituents that were manufactured via a refreeze/thawing route, were found to have excellent potential for antimicrobial delivery for bone infections. Cefuroxime Sodium with poly(ethylene glycol) was incorporated into 2 delivery systems poly(e-caprolactone) (PCL) and hydroxyapatite (HA), by a modified emulsion process. Our results indicate that the Cefuroxime Sodium released from poly(e-caprolactone) in PVA was tailored to a sustained release over more than 45 days, while the release from hydroxyapatite PVA reach burst maximum after 20 days. These PVA hydrogel-systems were also capable of controlled and sustained release of other biopharmaceuticals.