Is there a role of coral bone substitutes in bone repair?

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• 作者：Ippokratis Pountosp> ; p>p>pountos@doctors.org.ukp> ; Peter V. Giannoudis p>pgiannoudi@aol.comp>
• 关键词：Corals ; Mesenchymal stem cells ; Scaffold ; Bone healing ; Growth factors
• 刊名：Injury
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：47
• 期：12
• 页码：2606-2613
• 全文大小：448 K
• 卷排序：47

文摘

Xenogeneic bone graft materials are an alternative to autologous bone grafting. Among such implants, coralline-derived bone grafts substitutes have a long track record as safe, biocompatible and osteoconductive graft materials. In this review, we present the available literature surrounding their use with special focus on the commercially available graft materials. Corals thanks to their chemical and structural characteristics similar to those of the human cancellous bone have shown great potential but clinical data presented to date is ambiguous with both positive and negative outcomes reported. Correct formulation and design of the graft to ensure adequate osteo-activity and resorption appear intrinsic to a successful outcome.