Neonatal end-stage renal failure associated with maternal ingestion of cyclo-oxygenase-type-1 selective inhibitor nimesulide as tocolytic

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• 作者：Peruzzi ; Licia ; Gianoglio ; Bruno ; Porcellini ; Maria Gabriella ; Coppo ; Rosanna
• 刊名：The Lancet
• 出版年：1999
• 出版时间：November 6, 1999
• 年：1999
• 卷：354
• 期：9190
• 页码：1615
• 全文大小：28.5 K

文摘

Summary

Cyclo-oxygenase-type-2 (COX-2) enzyme is fundamental for nephrogenesis, upregulated on fetal membranes and myometrium at parturition. Fetal COX-2 inhibition, due to maternal nimesulide assumption, can be responsible for neonatal chronic renal failure.