Delta chemokine (fractalkine) – A novel mediator of pulmonary arterial hypertension in children undergoing cardiac surgery

详细信息    查看全文

• 作者：Tomer Avni ; Gideon Paret ; Avner Thaler ; David Mishali ; Salem Yishay ; Guy Tal ; Ilan Dalal
• 关键词：Fractalkine ; Cardiopulmonary bypass ; Cytokines ; Hypoxemia ; Pulmonary arterial hypertension
• 刊名：Cytokine
• 出版年：2010
• 出版时间：December 2010
• 年：2010
• 卷：52
• 期：3
• 页码：143-145
• 全文大小：164 K

文摘

Background

Fractalkine (FKN), a unique chemokine associated with pulmonary hypertension, may be involved in the acute stress response that regulates inflammation after cardiopulmonary bypass (CPB) surgery. We characterized FKN levels and correlated them with clinical parameters in children undergoing cardiac surgery involving CPB.

Methods

Twenty-seven consecutive patients, aged 30 days to 11.5 years, who underwent surgery for correction of congenital heart defects, were prospectively studied. Serial blood samples were collected preoperatively, upon termination of CPB, and at six points postoperatively. Plasma was recovered immediately, aliquoted, and frozen at −70 °C until assayed. Clinical and laboratory data were collected.

Results

Baseline FKN levels were skewed between patients. Patients with low FKN levels showed significantly higher levels of oxygen saturation in room air compared to patients with high FKN levels (p < 0.05). Moreover, there was a positive correlation between preoperative pulmonary arterial hypertension and FKN levels (p < 0.05). Surprisingly, FKN elevation from preoperative to postoperative levels displayed no discernible pattern.

Conclusions

FKN levels significantly correlate with preoperative hypoxemia and PAH, suggesting that FKN may be up-regulated during hypoxemia. CPB is not associated with acute changes in circulating FKN levels. The role of FKN in the postoperative course should be further investigated.