Outcome of patients with cystic fibrosis admitted to the intensive care unit: Is invasive mechanical ventilation a risk factor for death in patients waiting lung transplantation?

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• 作者：Ori Efrati ; Irena Bylin ; Eran Segal ; Daphna Vilozni ; Dalit Modan-Moses ; Amir Vardi ; Amir Szeinberg ; Gideon Paret
• 刊名：Heart Lung: The Journal of Acute and Critical Care
• 出版年：2010
• 出版时间：4 March 2010
• 年：2010
• 卷：39
• 期：2
• 页码：153-159
• 全文大小：177 K

文摘

Objective

The admission of patients with cystic fibrosis (CF) to the intensive care unit (ICU) is controversial. Our aim was to study the long-term outcome of patients with CF who were admitted to the ICU and the effect of ventilation modality.

Methods

The medical records of 104 admissions (1996-2006) of 48 patients with CF (age 18 ± 9 years) were reviewed. Seventeen patients were admitted with reversible conditions (group 1). Thirty-one patients were admitted for acute on chronic respiratory failure (group 2).

Results

In group 1, 16 of 17 patients survived up to 10 years from ICU admission. Conversely, in group 2, 23 of 31 patients (74 % ) died of respiratory failure. In group 2, 17 of 18 patients who were mechanically ventilated died within 90 days from admission, and 7 of 10 patients treated for prolonged periods with bi-level positive airway pressure are still alive up to 10 years after admission and transplantation.

Conclusion

Patients requiring mechanical ventilation may have a poor prognosis. The outcome of treatment with bi-level positive airway pressure is good, even in patients who had many episodes of acute respiratory failure.