Biomechanical Origins of Muscle Stem Cell Signal Transduction
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- 作者：James B. Morrissey1 ; 2 ; Richard Y. Cheng1 ; 2 ; Sadegh Davoudi1 ; 2 ; Penney M. Gilbert1 ; 2 ; penney.gilbert@utoronto.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：ECM ; extracellular matrix ; MSC ; mesenchymal stromal cell ; MRTF ; myocardin-related transcription factor ; MAPK ; mitogen-activated protein kinase ; MS ; mechanosensitive ; SA ; stretch-activated ; TRP ; transient receptor potential
- 刊名：Journal of Molecular Biology
- 出版年：2016
- 出版时间：10 April 2016
- 年：2016
- 卷：428
- 期：7
- 页码：1441-1454
- 全文大小：733 K
文摘
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Satellite cells are required to reconstruct skeletal muscle following tissue insult.
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A mechanistic comprehension of satellite cell regulation is still in its nascence.
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Soluble cues can synergize with biophysical niche features to direct stem cell fate.
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An emerging vision of satellite cell biophysical regulation is reviewed.