Tumor infiltrating lymphocytes in gastrointestinal tumors: Controversies and future clinical implications

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• 作者：Cinzia Solinasp>ap>p> ; p>p>czsolinas@gmail.comp> ; Grazia Pusolep>bp>p> ; p>p>grazia.pusole@gmail.comp> ; Laura Demurtasp>bp>p> ; p>p>lau.demi@tiscali.itp> ; Marco Puzzonip>bp>p> ; p>p>marcopuzzoni@gmail.comp> ; Roberta Masciap>bp>p> ; p>p>roboa@hotmail.itp> ; Gilberto Morganp>cp>p> ; p>p>Gilberto.Morgan@Skane.sep> ; Riccardo Giampierip>dp>p> ; p>p>riccardo.giampieri81@gmail.comp> ; Mario Scartozzip>bp>p> ; p>p>marioscartozzi@gmail.comp>
• 关键词：Tumor infiltrating lymphocytes ; Gastrointestinal tumors ; Microsatellite instability ; Prognosis ; Immunotherapy
• 刊名：Critical Reviews in Oncology/Hematology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：110
• 期：Complete
• 页码：106-116
• 全文大小：840 K
• 卷排序：110

文摘

Different techniques can be used for the assessment of tumor-infiltrating lymphocytes (TILs), providing information about the extent, composition, density and functional profile of the immune infiltrate with prognostic and predictive implications. High mutational load in microsatellite instable tumors is correlated with higher immune infiltration and better responses to the immune-checkpoint blockade. TILs might have future role in the selection of the ideal candidates for immunotherapy.